News Author: David Douglas
CME Author: Charles Vega, MD
2 Mei 2008
Pasien penderita asma dengan respon jelek terhadap terapi asma biasanya juga menderita rinitis sedang hingga berat, para peneliti dari Brazil mengemukakan issue ini pada Journal Allergi bulan Mei.
Sebagai seorang peneliti senor, Dr Alvaro A. Cruz menyampaikan pada Reuter Health , " artikel ini melaporkan adanya hubungan yang kuat antara rinitis sedang-berat dengan asma tidak terkontrol."
Dr. Cruz, dari Universidade Federal de Bahia dan rekan rekan juka menyatakan bahwa asma dan rhinitis memiliki beberapa kesamaan dan prevalensi rinitis cukup tinggi pada penderita asma.
Untuk meneliti lebih lanjut hubungan antara tiap kondisi, para peneliti melakukan studi prospectif pada sebanyak 557 penderita asma berat. Dari kesemuanya, 31% menderita rhinitis sedang-berat, 54% menderita rhinitis ringan dan 15% tanpa rhinitis.
Dibandingkan dengan subyek yang lain, pasien dengan asma sedang berat mengalami lebih dari 3 kali ((odds ratio, 3.83) harus mendatangi ruang gawat darurat dalam setahun untuk pemeriksaan/ follow up.
Diakhir pemeriksaan, mereka juga mengalami 3 kali lipat (odds ratio, 2.94) menunjukkan perbaikan sumbatan jalan nafas kurang dari 10% dan lebih dari 12 kali memiliki asma yang tidak terkontrol.
Tim ini menunjukkan korelasi positif antara keparahan rhinitis dengan keparahan asma dan adanya korelasi negatif dengan skore quality-of-life.
" Menjadi suatu pertimbangan agar pasien mendapatkan terapi yang terbaik untuk asma dan rhinitis" kata Dr. Cruz pada kesimpulan. " Dari sekian banyaknya penjelasan dari pengamatan inter-relationship menyatakan bahwa keduanya (rhinitis dan asma) merupakan manifestasi penyakit yang sama dari keseluruhan jalan nafas, dengan derajat keparahan saluran nafas atas dan bawah yang saling berkorelasi."
Allergy. 2008;63:564-569.
Reuters Health Information 2008. © 2008 Reuters Ltd.
Rhinitis Often Accompanies Hard-to-Control Asthma
News Author: David Douglas
CME Author: Charles Vega, MD
Disclosures
 | |
 | |
| Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™ for physicians; Family Physicians - up to 0.25 AAFP Prescribed credit(s) for physicians |
|
May 2, 2008 — Patients who have a poor response to asthma treatment are likely to also have moderate-to-severe rhinitis, Brazilian researchers report in the May issue of Allergy.
As senior investigator Dr. Alvaro A. Cruz told Reuters Health, "this article reports on strong evidence for an association between moderate-to-severe rhinitis and uncontrolled asthma."
Dr. Cruz, of Universidade Federal de Bahia, and colleagues also note that asthma and rhinitis share many similarities and the prevalence of rhinitis among asthmatics is high.
To further investigate the relationship between the conditions, the researchers prospectively studied 557 patients with severe asthma. In all, 31% had moderate to severe rhinitis, 54% had mild rhinitis and 15% had no rhinitis.
Compared to the other subjects, patients with moderate-to-severe rhinitis were more than 3 times as likely (odds ratio, 3.83) to visit the emergency room during a year of follow-up.
By the end of follow-up, they were also almost 3 times as likely (odds ratio, 2.94) to show a less than 10% improvement in airway obstruction and were more than 12 times as likely to have uncontrolled asthma.
The team found a positive correlation between the severity of rhinitis and severity of asthma, and a negative correlation with quality-of-life scores.
"Taking into consideration that the patients were receiving the best treatment options for asthma and rhinitis," Dr. Cruz said in conclusion, "the most likely explanation for the observed inter-relationship is that both rhinitis and asthma were manifestations of the same disease affecting the entire airway, for which the degree of severity of the upper and lower airway processes is correlated."
Allergy. 2008;63:564-569.
Reuters Health Information 2008. © 2008 Reuters Ltd.
